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How long does it take to get allopurinol out of your system? Peak levels of allopurinol are reached within 1.5 hours and 4.5 hours for its active metabolite. Allopurinol may be taken once daily. Normal serum uric acid levels are normally achieved within one to three weeks. It may take two to six weeks before allopurinol effectively reduces gout attacks.
Is it OK to take allopurinol during a gout attack? Your doctor may advise you not to start taking allopurinol until after an acute (bad) attack of gout has passed. If this isn't possible, it may be started while the gout isn't as bad. Allopurinol is taken as a tablet once a day. It's usually better to take it just after eating.

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